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Updated: Jul 12, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
When Dowd-Beckwith reaction meets photocatalysis
Zhichao Zhang1, Lipeng Qiao1,2, Kai Sun1
1College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. bingyu@zzu.edu.cn.
Abstract:
Dowd-Beckwith reaction stands as a highly efficient strategy for the construction of medium-sized carbocyclic frameworks. In recent years, the integration of photocatalysis has fundamentally advanced the Dowd-Beckwith reaction by offering a mechanistically distinct platform that effectively circumvents the intrinsic limitations of classical protocols. This review summarizes recent advances in photocatalytic Dowd-Beckwith ring-expansion reactions, categorizing existing methodologies by radical initiation mode and discussing their mechanistic features. It is hoped that this overview may offer useful insights for the diversified synthesis of medium-sized carbocycles and hopefully facilitate their further exploration in practical contexts.
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