Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Exon Recombination

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

de novo genes originate in regions of ancestrally closed chromatin.

Genetics·2026

Same author

No Evidence of Sexually Antagonistic Coevolution in Drosophila Reproductive Tract Transcriptomes.

Molecular biology and evolution·2025

Same author

Phylogenetic Relatedness Does not Predict Patterns of Parallel Transcriptome Adaptation in Drosophila.

Genome biology and evolution·2025

Same author

No evidence of sexually antagonistic coevolution in Drosophila reproductive tract transcriptomes.

bioRxiv : the preprint server for biology·2025

Same author

Adaptive gene expression parallelism in the male reproductive tract of two Drosophila species.

Genetics·2025

Same author

Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait.

Molecular biology and evolution·2025

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

Immunostaining of Whole-Mount Drosophila Testes for 3D Confocal Analysis of Large Spermatocytes

Immunostaining of Whole-Mount Drosophila Testes for 3D Confocal Analysis of Large Spermatocytes

Published on: August 27, 2020

Parallel transcriptome adaptation during recent evolution of the Drosophila testis.

Tiezheng Fan¹, David J Begun¹

¹Department of Evolution and Ecology, University of California, Davis, CA, 95616.

|July 10, 2026

Summary

This study compares gene expression in two fruit fly species, Drosophila melanogaster and D. simulans, across continents. It reveals how migration and natural selection influence gene expression during species expansion.

Keywords:

D simulans D. melanogaster local adaptation parallel evolution transcriptome

More Related Videos

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

Published on: September 11, 2014

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes

Published on: January 20, 2014

Related Experiment Videos

Last Updated: Jul 12, 2026

Immunostaining of Whole-Mount Drosophila Testes for 3D Confocal Analysis of Large Spermatocytes

Immunostaining of Whole-Mount Drosophila Testes for 3D Confocal Analysis of Large Spermatocytes

Published on: August 27, 2020

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

Published on: September 11, 2014

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes

Published on: January 20, 2014

Area of Science:

Evolutionary Biology
Genomics
Molecular Biology

Background:

Natural selection shapes gene expression during species expansion.
Parallel evolution studies the independent emergence of similar phenotypes.
Drosophila melanogaster is a model organism, while D. simulans is understudied.

Purpose of the Study:

Investigate the role of migration and selection in gene expression variation.
Conduct the first comparative continent-scale transcriptomic analysis of male reproductive tracts in D. melanogaster and D. simulans.
Analyze ancestral range populations for both species.

Main Methods:

Continent-scale transcriptomic analysis
Comparative analysis of male reproductive tract (testis and accessory gland)
Analysis of ancestral and newly colonized populations

Main Results:

Presents the first continent-scale transcriptomic analysis of D. melanogaster and D. simulans male reproductive tracts.
Compares gene expression variation across species and geographic ranges.
Investigates the impact of migration and selection on gene expression.

Conclusions:

Provides insights into how natural selection and migration shape gene expression during species expansion.
Highlights the importance of comparative transcriptomics in understanding evolutionary processes.
Establishes a foundation for future research on D. simulans evolution.