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Long-Term Hemodynamic Stabilization With TTR-Stabilizing Therapy and Pressure-Guided Management in ATTR

Jamschid Sedighi1, Bernhard Unsöld1, Priyanka Boettger1

  • 1Department of Cardiology and Angiology, Justus Liebig University Giessen, Giessen, Germany.

JACC. Case Reports
|July 10, 2026
PubMed

Insights

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) treatment with stabilizing therapy and pulmonary artery pressure (PAP) monitoring improved heart function. This case suggests PAP-guided management may aid ATTR-CM patients on disease-modifying drugs.

Area of Science:

  • Cardiology
  • Pharmacology
  • Medical Devices

Background:

  • Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is often underdiagnosed in heart failure with preserved ejection fraction (HFpEF).
  • Disease-modifying therapies for ATTR-CM can slow progression, but their long-term impact on hemodynamics is not fully understood.
Abstract

Keywords:
CardioMEMSamyloidosisheart failure with preserved ejection fraction (HFpEF)telemonitoringtransthyretin cardiomyopathy

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