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Updated: Jul 12, 2026
08:27
Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
Complete genome sequences from clinical isolates of neonatal meningitis Escherichia coli
Julia Ienes-Lima1, Nicolle Lima Barbieri1, Lisa K Nolan2
1Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Microbiology Resource Announcements
|July 10, 2026
Abstract:
Neonatal meningitis Escherichia coli (NMEC) is the most common gram-negative microorganism to cause meningitis in newborns. Here, we report the complete genome sequences of 29 NMEC strains isolated from the cerebrospinal fluid of infants with meningitis in the Netherlands from 1989 to 1997.
Insights
Neonatal meningitis Escherichia coli (NMEC) causes newborn meningitis. This study presents the complete genome sequences of 29 NMEC strains from Dutch infants, offering insights into this common gram-negative pathogen.
Area of Science:
- Microbiology
- Genomics
- Neonatal Infectious Diseases
Background:
- Neonatal meningitis Escherichia coli (NMEC) is a leading cause of bacterial meningitis in newborns.
- Gram-negative microorganisms, particularly E. coli, pose significant threats to neonatal health.
- Understanding the genetic makeup of NMEC is crucial for developing effective prevention and treatment strategies.
Purpose of the Study:
- To sequence and analyze the complete genomes of 29 NMEC strains.
- To provide genomic data for NMEC strains isolated in the Netherlands between 1989 and 1997.
- To contribute to the understanding of NMEC epidemiology and virulence factors.
Main Methods:
- Whole-genome sequencing of 29 NMEC isolates.
- Bioinformatic analysis of obtained genome sequences.
- Isolation of strains from cerebrospinal fluid of infants with meningitis.
Main Results:
- The complete genome sequences of 29 NMEC strains were successfully obtained.
- Genomic data provides a foundation for comparative genomics and evolutionary studies of NMEC.
- The study characterizes NMEC strains from a specific geographical region and time period.
Conclusions:
- The availability of these genome sequences facilitates further research into NMEC pathogenesis.
- This genomic resource aids in understanding the genetic diversity and evolution of NMEC.
- The findings support ongoing efforts to combat neonatal meningitis caused by E. coli.
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