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The Role of miR-501-3p in Abdominal Aortic Aneurysm Progression: A Pilot Study

Hiroki Mine1, Kensuke Toyama2,3,4, Kenshi Yoshimura5

  • 1Division of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, 67 Asahi, Kurume, Fukuoka, 830-0011, Japan.

Journal of Cardiovascular Translational Research
|July 10, 2026
PubMed

Insights

Low expression of microRNA-501-3p (miR-501-3p) is linked to abdominal aortic aneurysm (AAA) presence and expansion. This finding suggests miR-501-3p may serve as a key biomarker for AAA.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • MicroRNA-501-3p (miR-501-3p) is implicated in vascular damage and arterial stiffness.
  • The specific role of miR-501-3p in abdominal aortic aneurysm (AAA) pathogenesis is not well understood.

Purpose of the Study:

  • To investigate the association between miR-501-3p expression levels and the presence and severity of AAA.
  • To explore miR-501-3p as a potential diagnostic or prognostic biomarker for AAA.

Main Methods:

  • Extraction of exosomal microRNAs from blood samples of patients.
  • RNA extraction from abdominal aortic aneurysm tissue, including areas of maximum dilation and transition zones.
  • Quantitative analysis of miR-501-3p expression and statistical correlation with AAA presence and size.

Main Results:

  • Lower blood miR-501-3p expression was significantly associated with the presence of AAA (OR=6.467, p<0.05).
  • AAA patients exhibited lower miR-501-3p levels in blood and tissue compared to controls.
  • Reduced miR-501-3p expression in AAA tissue correlated with larger aneurysm size, with low expression linked to aneurysms ≥55 mm.

Conclusions:

  • MicroRNA-501-3p expression is significantly reduced in patients with abdominal aortic aneurysm.
  • Low miR-501-3p levels may indicate the presence and predict the expansion of AAA.
  • miR-501-3p shows potential as a key regulator and biomarker for AAA.
Keywords:
Abdominal aortic aneurysmBlood exosomeMiR-501-3p

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