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Normal Reference Range of the Urinary Calcium/Creatinine Ratio in Healthy Children

Vaibhav D Lokhande1, Vaishali S Patil2, Suhas P Kulkarni3

  • 1Department of Biochemistry, D. Y. Patil Medical College, D.Y. Patil Education Society (Deemed to be University), Kolhapur, India.

Indian Journal of Pediatrics
|July 10, 2026
PubMed

Insights

This study establishes normal urinary calcium-to-creatinine ratio ranges for children aged 7-12 in Kolhapur. These age-specific values aid in diagnosing childhood hypercalciuria and related calcium disorders.

Area of Science:

  • Pediatric Nephrology
  • Clinical Biochemistry
  • Public Health

Background:

  • Accurate reference ranges for urinary calcium-to-creatinine ratio (UCa/Cr) are essential for diagnosing pediatric hypercalciuria.
  • Existing UCa/Cr reference ranges may not be applicable to diverse pediatric populations.
  • Establishing local, age-specific data is crucial for effective clinical management.

Purpose of the Study:

  • To determine age-specific normal reference ranges for urinary calcium-to-creatinine ratio (UCa/Cr).
  • To study healthy children aged 7-12 years in the urban Kolhapur region.
  • To provide data for accurate diagnosis and management of calcium disorders in children.

Main Methods:

  • 358 healthy children aged 7-12 years were enrolled.
  • Second-morning, non-fasting urine samples were collected.
  • Urinary calcium was analyzed using the Cresolpthalein complexone spectrophotometric method, and creatinine by the Modified Jaffe's method.

Main Results:

  • The mean UCa/Cr ranged from 0.12 ± 0.08 mg/mg at age 7 to 0.09 ± 0.02 mg/mg at age 12.
  • The highest mean UCa/Cr was observed at age 8 (0.15 ± 0.05 mg/mg).
  • The normal reference range for UCa/Cr in this population was 0.05 ± 0.192 mg/mg, showing a decline with age.

Conclusions:

  • Population-specific reference values for UCa/Cr are vital for diagnosing hypercalciuria in children.
  • This study provides essential clinical data for the Kolhapur region.
  • Early detection and management of calcium metabolism disorders in children are facilitated by these findings.
Abstract

Keywords:
HypercalciuriaUrinary calciumUrinary calcium-to-creatinine ratioUrinary creatinine

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