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Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
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Published on: September 28, 2022

Neurocognitive and affective dysfunction in Chiari malformation type I.

William Davalan1,2, Neel H Mehta1, Andrew T Hale3

  • 11Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.

Journal of Neurosurgery. Pediatrics
|July 10, 2026
PubMed
Summary
This summary is machine-generated.

Chiari malformation type I (CM-I) is increasingly viewed as a brain network disorder, not just structural. Evidence shows CM-I can cause cognitive and affective issues due to cerebellar dysfunction.

Keywords:
Chiari malformation type ISchmahmann syndromecerebellar cognitive affective syndromecerebellumcognitioncongenital

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Last Updated: Jul 12, 2026

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
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Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Chiari malformation type I (CM-I) is traditionally seen as a structural posterior cranial fossa disorder.
  • Emerging evidence links CM-I to neurocognitive and affective issues stemming from cerebellar network dysfunction.

Purpose of the Study:

  • To systematically review neuropsychological outcomes in pediatric and adult CM-I patients.
  • To synthesize findings on cognitive and affective sequelae associated with CM-I.

Main Methods:

  • Conducted a PRISMA-compliant systematic review of MEDLINE and Embase databases.
  • Included 34 studies with 2113 participants diagnosed with CM-I.
  • Synthesized data using a structured narrative approach due to heterogeneity.

Main Results:

  • Observed consistent cognitive vulnerabilities in attention, executive function, visuospatial processing, memory, language, and social cognition.
  • Cognitive profiles resembled cerebellar cognitive affective syndrome and varied by developmental stage.
  • Neuroimaging revealed disrupted cerebello-thalamo-cortical and cortico-ponto-cerebellar networks.

Conclusions:

  • Reconceptualize CM-I as a heterogeneous brain network disorder with potential cognitive and affective consequences.
  • Neuropsychological assessment is crucial for prognostication and guiding interventions.
  • Further research is needed to understand mechanism-based interventions.