Related Experiment Video
Updated: Jul 12, 2026
06:10
Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
Published on: August 23, 2022
The enterohepatic bile acid axis: from perinatal programming to metabolic collapse
Haiyue Lin1, Jingjing Ye2, Qiufang Bai3
1Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Biochemical and Biophysical Research Communications
|July 10, 2026
Summary
The bile acid system
Area of Science:
- Molecular biology
- Developmental biology
- Metabolic research
Background:
- The enterohepatic bile acid system's developmental and adaptive changes are not fully understood.
- Bile acids play critical roles in digestion, metabolism, and signaling pathways.
Purpose of the Study:
- To profile bile acid metabolism genes during liver development, tissue distribution, fasting-refeeding, and in MASH models.
- To define the spatial and temporal regulation of bile acid homeostasis.
Main Methods:
- Gene expression profiling across different physiological states and disease models.
- Analysis of key regulatory loops like FXR-SHP and FGF15 signaling.
Main Results:
- Bile acid synthesis genes activate during perinatal development, with the FXR-SHP loop functional from birth.
- Adult bile acid homeostasis shows hepatic synthesis and ileal reabsorption/FGF15 signaling, indicating spatial compartmentalization.
- Metabolic flexibility during fasting is lost in MASH models, showing FXR-SHP uncoupling or transcriptional collapse.
Conclusions:
- The bile acid metabolic program is precisely regulated across development and space.
- This program is flexibly tuned to nutritional status but is dismantled by chronic metabolic injury.
- Disruption of bile acid homeostasis may be an early event in MASH pathogenesis.
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