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Updated: Jul 12, 2026
06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Smart deep eutectic solvents in analytical chemistry: From responsive materials to advanced membrane-based sample
Dhandapani Ramesh1, Gracia Saral Gladison1, Udayakumar Mani1
1Green Separation Engineering Laboratory, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.
Talanta
|July 10, 2026
Summary
Smart deep eutectic solvents (smart DES) offer dynamic control in analytical chemistry, enabling enhanced selectivity and reusability. These switchable solvents represent a promising direction for next-generation analytical platforms.
Area of Science:
- Analytical Chemistry
- Materials Science
- Supramolecular Chemistry
Background:
- Deep eutectic solvents (DES) are increasingly used as green alternatives in analytical chemistry.
- Smart DES are a novel class of designer solvents with stimulus-responsive properties.
- Conventional DES lack dynamic control, limiting their application scope.
Purpose of the Study:
- To review the classification, stimulus-response mechanisms, and analytical applications of switchable DES.
- To highlight membrane-based analytical formats utilizing smart DES.
- To evaluate challenges and future directions for smart DES in analytical chemistry.
Main Methods:
- Critical discussion of smart DES classification and stimulus-response mechanisms.
- Review of applications in liquid-phase microextraction, chromatography, electrophoresis, and sensors.
- Evaluation of challenges including viscosity, stability, and standardization.
Main Results:
- Smart DES enable dynamic control over extraction, separation, and detection, enhancing selectivity and reusability.
- Applications span microextraction of pollutants and biomolecules, tunable chromatography phases, and responsive sensors.
- Membrane-based formats like switchable supported liquid membranes show significant potential.
Conclusions:
- Smart DES transition analytical chemistry from static solvents to dynamic functional materials.
- Further research is needed for rational design, integration into automated systems, and exploration of supramolecular/chiral variants.
- Smart DES offer a promising pathway for next-generation analytical chemistry with improved performance and automation capabilities.
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