Anin vitrostudy of osteogenic and antibacterial properties of ZnO-BaTiO₃coated titanium

The research and development of artificial bone materials has become the focus of clinical bone tissue engineering research. Currently, surface modification is often used to give titanium excellent bone regeneration ability and antibacterial properties without changing its mechanical properties and biocompatibility. In this study, ZnO/BT coating (ZnO/BT-Ti) was successfully prepared on pure Ti surface by hydrothermal, in order to obtain titanium based artificial bone material with excellent osteogenic and antibacterial properties. ZnO/BT coating material did not show obvious cytotoxicity, and the coating material used in this study had good cytocompatibility. Compared with Ti, BT-Ti effectively promoted the expression of osteoblast-related genes and proteins in MC3T3-E1 cells, and ZnO/BT coating material further enhanced the promotion of bone differentiation of cells. Additionally, ZnO/BT-Ti significantly inhibited the proliferation of P.g and the formation of biofilm. Therefore, ZnO/BT composite ceramic coating has a synergistic effect on osteogenic differentiation of MC3T3-E1 cells, and significant antibacterial properties, providing the preliminary experimental support for the development of new artificial bone materials.