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Updated: Jul 12, 2026

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High-performance dosimetric gel for low-dose-rate 3D-printed brachytherapy devices.

Mahdokht Akbari-Taemeh1, Anna-Kim Péron1, Theophraste Lescot2

  • 1Axe Oncologie, CHUQ, 2705, boul. Laurier, Québec City, Quebec, G1V 4G2, Canada.

Physics in Medicine and Biology
|July 10, 2026
PubMed
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Roadmap: medical physics technologies in brachytherapy.

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A new MAGIC-pf gel dosimeter shows excellent stability and water equivalency for low-dose-rate brachytherapy, enabling precise dose delivery in eye cancer treatments using 125I seeds.

Area of Science:

  • Medical Physics
  • Radiotherapy Dosimetry
  • Biomedical Engineering

Background:

  • Traditional gel dosimeters face limitations in low-energy photon brachytherapy due to stability and water equivalency issues.
  • Low-dose-rate (LDR) brachytherapy, particularly for eye cancers using isotopes like 125I, requires precise dosimetry.
  • Existing dosimetric methods struggle with the specific challenges of LDR brachytherapy applications.

Purpose of the Study:

  • To develop and optimize a novel dosimetric gel (MAGIC-pf) for low-energy photon brachytherapy.
  • To evaluate the performance of MAGIC-pf gel with 125I radioactive seeds in 3D-printed brachytherapy implants.
  • To assess the gel's suitability for precise dose distribution measurements in ocular treatments.

Main Methods:

  • Optimized the MAGIC gel formulation using agarose (MAGIC-a) and paraformaldehyde (MAGIC-pf).
Keywords:
3D printingMAGIC gelsT&lt;sub&gt;2&lt;/sub&gt; maps in magnetic resonance imaging (MRIdosimetry gelsdosimetry gels for low-dose-rate brachytherapyhigh-dose-rate brachytherapy (HDR-BT)low-dose-rate brachytherapy (LDR-BT)

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  • Assessed thermal/temporal stability and self-polymerization using MRI and NMR relaxometry.
  • Evaluated water equivalency via Monte Carlo simulations and measured radiation sensitivity to 125I and 192Ir sources.

    • Main Results:

    • MAGIC-pf gel exhibited superior thermal and temporal stability and enhanced MRI readout performance.
    • Measured sensitivity of MAGIC-pf to 125I seeds ranged from 0.1 to 0.388 Gy-1.s-1 across 1.5T and 3T MRI.
    • 3D-printed implants with 125I seeds demonstrated reproducible, precise dose distributions visualized in 2D and 3D.

    Conclusions:

    • MAGIC-pf gel offers excellent stability, water equivalency, and compatibility with both LDR and HDR brachytherapy.
    • The sub-millimetric dose profiles achieved are ideal for personalized, next-generation 3D-printed brachytherapy implants.
    • This novel gel dosimeter advances precision dosimetry for advanced brachytherapy techniques.