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Updated: Jul 12, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Diterpenoids from Euphorbia prolifera and their anti-inflammatory activity
Fei Lin1, Yang Xu1, Yunrong Wang1
1Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Abstract:
Seven previously undescribed diterpenoids, including three myrsinane diterpenoids (1-3), one premyrsinane diterpenoid (4), two tigliane (5-6) and one bicyclic diterpenoid (7), as well as eight known myrsinane-type diterpenoids (8-15) have been isolated from the dried roots of Euphorbia prolifera Buch.-Ham. ex D. Don. The structures of the previously undescribed diterpenoids were determined by HR-ESI-MS, 1D and 2D NMR, ECD and other methods. Meanwhile, all compounds were evaluated for their anti-inflammatory activity in vitro, and the results showed that compounds 5, 8 and 10 showed significant inhibitory effect on NO production induced by LPS in RAW 264.7 macrophages, compared to the positive control drug dexamethasone.
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