FLASH radiation therapy mitigates immunogenic and pro-fibrotic transcriptomic responses in healthy lung tissue
Adrien Arrigo1, Louize Brants1, Verdi Vanreusel1
1Antwerp Research in Radiation Oncology (AReRO), Center for Oncological Research (CORE), University of Antwerp, Wilrijk, Antwerp, Belgium.
Abstract:
To investigate why FLASH-radiation therapy (RT) minimises lung damage, we performed bulk RNA-sequencing at 24 h and 2 weeks post-irradiation. Unlike conventional dose-rate RT, FLASH did not induce acute chemokine enrichment associated with NFKB1 upregulation and prevented sustained transcriptional activation of genes involved in macrophage activation, chemotaxis, and differentiation.
