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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: Jul 12, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Mapping epigenetic alterations across brain tumor hallmarks.

Celeste Antonacci1, Luana Abballe1, Angela Di Giannatale1

  • 1Onco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Biochimica Et Biophysica Acta. Reviews on Cancer
|July 10, 2026
PubMed
Summary
This summary is machine-generated.

Epigenetic alterations drive brain tumor growth and progression. Targeting these reversible changes offers a promising therapeutic avenue, though challenges in understanding the brain tumor epigenome and drug delivery remain.

Keywords:
Brain tumorsEpigenetic drugsEpigeneticsHallmarks of cancer

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Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres
09:31

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres

Published on: January 29, 2018

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Last Updated: Jul 12, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres
09:31

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres

Published on: January 29, 2018

Area of Science:

  • Neuro-oncology
  • Cancer epigenetics
  • Molecular biology

Background:

  • Malignant brain tumors, including glioblastoma and pediatric brain cancers, are aggressive with poor survival rates.
  • Dysregulated epigenetic control is a critical driver of brain tumor initiation and progression.
  • Epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNAs) influence gene expression and cancer hallmarks.

Purpose of the Study:

  • To review key epigenetically regulated genes and microRNAs in major brain tumor types.
  • To link these epigenetic alterations to specific cancer hallmarks.
  • To highlight epigenetic therapies targeting oncogenic processes.

Main Methods:

  • Literature review of epigenetic mechanisms in brain tumors.
  • Analysis of epigenetically regulated genes and microRNAs.
  • Summary of current epigenetic therapies and their targets.

Main Results:

  • Identified critical epigenetic alterations in various brain tumors.
  • Connected epigenetic dysregulation to cancer hallmarks.
  • Showcased promising epigenetic drugs in preclinical and clinical studies.

Conclusions:

  • Epigenetic mechanisms are central to brain tumorigenesis and are potentially reversible therapeutic targets.
  • Further understanding of the brain tumor epigenome is needed for effective clinical application of epigenetic drugs.
  • Epigenetic therapies hold promise for treating aggressive brain tumors by targeting oncogenic pathways.