Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Elaborative Rehearsals01:07

Elaborative Rehearsals

Elaborative rehearsal is a crucial cognitive strategy that strengthens information encoding in long-term memory by making meaningful connections between new data and pre-existing knowledge. This approach contrasts with maintenance rehearsal, which involves simple repetition without delving into the significance of the information. While maintenance rehearsal might temporarily keep information active in short-term memory, it is less effective for long-term retention.
The effectiveness of...
Asexual Reproduction02:38

Asexual Reproduction

Asexual reproduction allows plants to reproduce without growing flowers, attracting pollinators, or dispersing seeds. Offspring are genetically identical to the parent and produced without the fusion of male and female gametes.
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KChIP4a is a Biophysical Amplifier of Inhibition in Atypical Dopamine Neurons and Controls Learning from Negative Prediction Errors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions.

Nucleic acids research·2025
Same author

Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7.

Science advances·2025
Same author

AMP-activated protein kinase mediates adaptation of glioblastoma cells to conditions of the tumor microenvironment.

Journal of experimental & clinical cancer research : CR·2025
Same author

Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate.

The EMBO journal·2025
Same author

Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax.

PLoS genetics·2025

Related Experiment Video

Updated: Jul 12, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

A Hox/TALE workshop revival.

Samir Merabet1, Dorothea Schulte2

  • 1IGFL, CNRSUMR5242, ENS Lyon, Université Lyon I, 32/34 Av. Tony Garnier, Lyon, 69007, France.

Developmental Biology
|July 10, 2026
PubMed
Summary

Hox and TALE transcription factors are crucial for development and disease. This workshop explored their complex roles, revealing new insights into congenital conditions and disease prediction using model organisms and advanced technologies.

More Related Videos

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy
06:35

Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy

Published on: September 30, 2013

Related Experiment Videos

Last Updated: Jul 12, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy
06:35

Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy

Published on: September 30, 2013

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Hox and TALE homeodomain (HD) proteins are conserved transcription factors essential for embryonic development, establishing spatial-temporal patterns.
  • These proteins also regulate numerous functions in adult life, and their aberrant expression is linked to congenital diseases and malformations.

Purpose of the Study:

  • To review recent advances in Hox/TALE biology, focusing on their roles in developmental regulatory networks and disease states.
  • To explore whether mutations or variants in Hox/TALE genes, or associated genes, can be predicted from model organism research.
  • To foster discussion and collaboration among researchers in the Hox/TALE field.

Main Methods:

  • The workshop integrated findings from various animal model systems and regulatory pathways.
  • It highlighted the application of cutting-edge technologies and bioinformatics tools for in vivo analysis.
  • Discussions involved senior and junior researchers to address key questions in Hox/TALE biology.

Main Results:

  • Novel functional and molecular aspects of Hox and TALE proteins were revealed in different model systems.
  • The power of recent technologies and bioinformatics in deciphering Hox/TALE molecular complexity was demonstrated.
  • The workshop identified key questions for future research in developmental biology and disease states.

Conclusions:

  • Hox and TALE transcription factors play critical, multifaceted roles in development and disease.
  • Model organisms and advanced technologies are powerful tools for understanding Hox/TALE function and predicting disease associations.
  • The Hox/TALE research community is dynamic and poised for future breakthroughs.