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Updated: Jul 12, 2026

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40 Hz-rTMS modulates spike-LFP coupling and improves cognitive function in 5xFAD mice.

Qianhui Ma1, Zixiang Ding1, Ruru Wang1

  • 1State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Neuromodulation and Neurorepair, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.

Experimental Neurology
|July 10, 2026
PubMed
Summary

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This summary is machine-generated.

Alzheimer

Area of Science:

  • Neuroscience
  • Neurophysiology
  • Alzheimer's Disease Research

Background:

  • Spike-local field potential (LFP) coupling is crucial for neural communication.
  • Abnormal coupling is implicated in Alzheimer's disease (AD), but in vivo data are limited.
  • 5XFAD mouse models offer an in vivo platform to study AD-related neural deficits.

Purpose of the Study:

  • To characterize in vivo spike-LFP coupling in the hippocampus of 5XFAD mice.
  • To investigate the therapeutic potential of 40 Hz repetitive transcranial magnetic stimulation (rTMS) in ameliorating deficits.
  • To explore the correlation between neural coupling and cognitive function in AD models.

Main Methods:

  • Chronic in vivo electrophysiological recordings of spikes and LFPs in the hippocampal dentate gyrus.
Keywords:
Alzheimer's diseaseGamma stimulationRepetitive transcranial magnetic stimulation (rTMS)Spike-LFP coupling

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  • Phase-locking and coherence analysis to quantify spike-LFP coupling.
  • Cognitive assessments (Y-maze, novel object recognition, Morris water maze) and correlation analysis.

    • Main Results:

    • 5XFAD mice showed significantly reduced spike-LFP coupling (spike-θ and spike-Hγ) compared to wild-type controls.
    • 14 days of 40 Hz rTMS treatment significantly increased spike-LFP coupling in 5XFAD mice.
    • rTMS intervention markedly improved cognitive functions, including learning, memory, and flexibility, correlating with improved neural coupling.

    Conclusions:

    • 40 Hz rTMS effectively modulates pathological spike-local field potential coupling in a mouse model of Alzheimer's disease.
    • These findings support rTMS as a potential therapeutic strategy for AD.
    • Further research is warranted to explore rTMS for clinical application in AD patients.