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Related Concept Videos

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Implementation of a Multidisciplinary Radiopharmaceutical Dosimetry Program: Key Practical Considerations and

Mustafa M Basree1, Abby Besemer1, Tyler Bradshaw2

  • 1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

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|July 10, 2026
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Summary

Establishing a multidisciplinary radiopharmaceutical therapy (RPT) dosimetry program is feasible. This framework integrates nuclear medicine and radiation oncology for personalized RPT treatments.

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Area of Science:

  • Nuclear Medicine and Radiation Oncology
  • Medical Physics
  • Radiopharmaceutical Therapy

Background:

  • Radiopharmaceutical therapy (RPT) is a growing multidisciplinary treatment. Dosimetry in RPT is crucial for prognosis, treatment decisions, and personalized care. Implementing an RPT dosimetry program requires significant interdepartmental coordination.
  • Establishing an institutional RPT dosimetry program necessitates collaboration among clinical, technical, and administrative teams for patient-specific absorbed dose calculations.

Purpose of the Study:

  • To summarize the University of Wisconsin's experience in developing and operationalizing a multidisciplinary clinical RPT dosimetry program.
  • To offer a practical framework for other institutions seeking to establish similar RPT dosimetry programs.
  • To leverage the combined strengths of radiation oncology and nuclear medicine physicians, medical physicists, and staff.

Main Methods:

  • The program was developed through collaboration among radiation oncology, nuclear medicine, medical physics, radiation safety, and nuclear pharmacy.
  • Core elements included quantitative SPECT/CT imaging, multi-timepoint image registration, voxel-level Monte Carlo dose calculation, and structured multidisciplinary patient review.
  • Standardized quality assurance processes and a billing model were implemented for accuracy, reproducibility, and streamlined cost recovery.

Main Results:

  • Multi-timepoint RPT dosimetry is feasible and can be integrated into routine clinical workflows.
  • The University of Wisconsin program demonstrates successful operationalization with appropriate infrastructure, interdepartmental coordination, and leadership support.
  • Utilizing interdepartmental expertise is key to an effective RPT dosimetry program.

Conclusions:

  • Successful RPT dosimetry programs require early stakeholder engagement, harmonized imaging protocols, and streamlined data management.
  • Broader adoption of RPT dosimetry can be facilitated by standardized reimbursement models, national quality assurance standards, and educational initiatives.
  • Preparing radiation oncology and nuclear medicine teams for patient-specific RPT care is essential for advancing the field.