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MND1 regulates PANoptosis and stemness of lung adenocarcinoma cells by stabilizing RCOR2 mRNA

Lianlian Ouyang1,2, Xingjie Tang1, Shiyao Jiang1

  • 1School of Basic Medical Sciences, Hunan Normal University Health Science Center, Hunan Normal University, Changsha, Hunan, China.

Cell Death & Disease
|July 10, 2026
PubMed

Insights

Meiotic nuclear division protein 1 (MND1) stabilizes RCOR2 mRNA, promoting lung adenocarcinoma stemness and inhibiting PANoptosis. This study reveals MND1

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Death Mechanisms

Background:

  • PANoptosis is an inflammatory programmed cell death pathway involving the PANoptosome complex.
  • Meiotic nuclear division protein 1 (MND1) is a meiosis-specific protein with unclear roles in cancer.
  • The regulation of tumor stemness and cell death in lung adenocarcinoma (LUAD) is critical for disease progression.

Purpose of the Study:

  • To investigate the role of MND1 in regulating PANoptosis and tumor stemness in LUAD.
  • To elucidate the molecular mechanisms by which MND1 influences LUAD pathogenesis.

Main Methods:

  • Investigated MND1's function in LUAD cell lines.
  • Analyzed the interaction between MND1, PABPC1, and RCOR2 mRNA.
  • Assessed the impact of MND1 on PANoptosis and stemness markers.

Main Results:

  • MND1 was found to recruit PABPC1, enhancing the stability of RCOR2 mRNA.
  • Stable RCOR2 expression is crucial for maintaining LUAD cell stemness.
  • MND1 acts as an oncogene by stabilizing RCOR2, thereby maintaining stemness and inhibiting PANoptosis in LUAD.

Conclusions:

  • MND1 plays a significant role in promoting LUAD stemness and inhibiting PANoptosis.
  • MND1 functions as an oncogene in LUAD through RCOR2 mRNA stabilization.
  • This study provides novel insights into the interplay between MND1, stemness, and PANoptosis in LUAD.

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