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Related Concept Videos

Stress Prevention and Stress Management Techniques II01:23

Stress Prevention and Stress Management Techniques II

Personality types, particularly Type A and Type B, significantly influence how individuals respond to stress. These personality distinctions are marked by varying levels of ambition, competitiveness, and coping styles, all of which shape an individual's resilience to stressors.
Type A Personality: Driven and Easily Stressed
Individuals with Type A personalities are often highly competitive and ambitious and operate with a strong sense of urgency. Commonly labeled as "workaholics," they...
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
Stress Prevention and Stress Management Techniques I01:26

Stress Prevention and Stress Management Techniques I

Stress prevention and management are crucial for maintaining well-being and building resilience. Techniques to manage stress include cultivating qualities like conscientiousness, a sense of personal control, and self-efficacy. Each of these traits significantly reduces stress and promotes healthier lifestyle choices and outcomes.
Conscientiousness
Conscientious individuals tend to be organized, responsible, and disciplined. They prioritize completing tasks and following structured routines,...
Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

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Related Experiment Video

Updated: Jul 12, 2026

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Stress-coping phenotypes shape adipose tissue function and plasticity and modulate metabolic resilience.

Saumya Kishor Mehta1, Michaella Ben-Shachar1, Sharmila Govindaraj1

  • 1School of Biomedical Sciences, Faculty of Medicine, Ariel University, Ariel, Israel.

Translational Psychiatry
|July 10, 2026
PubMed
Summary

Stress resilience protects against metabolic disease by maintaining healthy adipose tissue function. Impaired stress coping in mice led to poor fat cell development and increased obesity susceptibility.

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Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice
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Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

Area of Science:

  • Metabolic research
  • Obesity research
  • Stress and physiology

Background:

  • Stress resilience confers metabolic protection, particularly in high-fat diet (HFD) models.
  • Adipose tissue is central to obesity comorbidities.
  • Understanding how stress resilience impacts adipose tissue is crucial.

Purpose of the Study:

  • To define how stress resilience influences adipose tissue function.
  • To investigate the molecular and transcriptomic changes in adipose tissue of stress-resilient (Dominant, Dom) versus stress-vulnerable (Submissive, Sub) mice under standard (STD) or HFD.
  • To assess the effects of pioglitazone and paroxetine on adipose tissue function.

Main Methods:

  • Comparative analysis of Dom and Sub mice under STD and HFD conditions.
  • Metabolic, molecular, and transcriptomic analyses of epididymal and inguinal white adipose tissue (eWAT and iWAT).
  • Isolation of stromal vascular fraction (SVF) cells to assess adipogenic potential; investigation of drug effects (pioglitazone, paroxetine).

Main Results:

  • Sub mice on HFD developed glucose intolerance and impaired insulin signaling, unlike metabolically protected Dom mice.
  • Sub WAT showed adipocyte hypertrophy, unfavorable leptin/adiponectin ratios, and suppressed BCAA catabolism.
  • Sub mice exhibited reduced SVF cell proliferation and adipogenic potential, with transcriptomic evidence of downregulated adipogenesis.
  • Dom adipocytes showed higher Glut4, Ucp1, and favorable adiponectin/leptin mRNA ratios.
  • Pioglitazone improved adipogenesis and insulin sensitivity in Sub mice; paroxetine normalized behavior and improved adipogenesis towards a Dom-like profile.

Conclusions:

  • Impaired stress coping is linked to defects in adipose progenitor function.
  • These defects contribute to maladaptive white adipose tissue (WAT) expansion and increased susceptibility to metabolic disease.
  • Targeting stress response and adipose progenitor function may offer therapeutic strategies for obesity-related metabolic dysfunction.