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Timing is everything: outcomes of allogeneic HSCT in adults with inborn errors of immunity

Katharine Orf1,2, Hannah Al Yousuf2, Thomas A Fox1,2

  • 1Institute of Immunity & Transplantation, University College London, London, UK.

Bone Marrow Transplantation
|July 10, 2026
PubMed

Insights

Early referral for adult Inborn Errors of Immunity (IEI) patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is crucial. Patients deemed too high-risk for HSCT face significantly poorer survival rates.

Area of Science:

  • Immunology
  • Hematology
  • Transplantation Medicine

Background:

  • Inborn Errors of Immunity (IEI) are a group of rare genetic disorders affecting the immune system.
  • Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is a potentially curative treatment for severe IEI.
  • International Multidisciplinary Team (MDT) assessment is often employed for complex cases.

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