Related Experiment Video

Updated: Jul 12, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Protein stability is determined by single-site bias rather than pairwise covariance

Matt Sternke1,2, Katherine W Tripp1, Soumya Prakash Behera1

  • 1T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA.

Nature Chemical Biology
|July 10, 2026
PubMed
Abstract

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