Related Experiment Video For Bladder cancer
Updated: Jul 12, 2026
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Immunohistochemical evaluation of molecular subtypes in muscle invasive bladder cancer with demographic correlation
Pranita Mohanty1, Megha Subhangini2
1Dept of Pathology, IMS & SUM Hospital, Siksha'O'Anusandhan University, Bhubaneswar, Odisha, 751003, India. pranitamohanty@soa.ac.in.
Background:
Muscle-invasive bladder cancer (MIBC) is a biologically heterogeneous malignancy with variable clinical outcomes. Molecular subtyping has improved understanding of tumor biology and therapeutic stratification.
Materials And Methods:
This retrospective study included 64 cases of MIBC. Immunohistochemistry (IHC) was performed using GATA3, CK5/6, p53, and FGFR3 to classify tumours into molecular subtypes. HER2 expression was also evaluated and correlated with clinicopathological parameters.
Results:
Luminal subtype was predominant (76.6%). CK5/6 positivity was observed in 38.3% of cases. Aberrant p53 expression was noted in 79.8% of tumours. FGFR3 expression was detected in 17% of cases and was significantly associated with luminal subtype. HER2 overexpression was more frequent in luminal tumours. Basal tumours showed better response to neoadjuvant chemotherapy, whereas luminal tumours demonstrated higher FGFR3 and HER2 expression. p53-altered tumours showed features of chemoresistance.
Conclusion:
IHC-based molecular classification is a practical surrogate for transcriptomic profiling in MIBC and may assist in prognostication and therapeutic decision-making.
More Related Videos
09:243-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013