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A three-level risk stratification algorithm for arrhythmia based on CNN-LSTM palindromic structure
Hua Zhang1,2,3, Jing Li4,5,6, Mingjie Wang1,2,3
1Department of Cardiology, Zhengzhou Seventh People's Hospital, Zhengzhou, 450000, China.
Insights
This study introduces a deep learning algorithm for three-level arrhythmia risk stratification using electrocardiogram (ECG) signals. The novel approach accurately detects and classifies arrhythmia risks, enabling timely intervention and optimized resource allocation.
Area of Science:
- Biomedical Engineering
- Artificial Intelligence in Medicine
- Cardiology
Background:
- Cardiovascular diseases necessitate early screening and intervention due to high mortality and recurrence rates.
- Real-time electrocardiogram (ECG) monitoring is challenging due to limited medical resources and complex ECG signal features.
- Accurate arrhythmia detection and risk stratification are crucial for effective patient management.
Purpose of the Study:
- To develop a three-level risk stratification algorithm for arrhythmias using ECG signals.
- To enhance the accuracy of arrhythmia detection and risk assessment.
- To optimize medical resource allocation through precise intervention strategies.
Main Methods:
- Proposed a three-level risk stratification scheme: Normal, Not Life-threatening, and Life-threatening.
- Developed a deep learning fusion network combining Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM) with a palindromic structure.
- Utilized multi-dataset experiments and cross-validation for performance evaluation.
Main Results:
- The algorithm achieved high accuracy (99.68%) and specificity (99.65%) on 2-second ECG segments.
- 10-fold cross-validation showed 99.62% ± 0.09% accuracy on 3-second segments.
- Patient-level validation on 10-second segments yielded 96.5% accuracy, demonstrating reliability across varied segment lengths.
Conclusions:
- The proposed deep learning algorithm effectively performs three-level arrhythmia risk stratification and detection.
- The method demonstrates superior performance compared to standalone CNN, LSTM, and classical classifiers.
- The algorithm offers a reliable and practical solution for improving cardiovascular disease management and resource allocation.
Abstract:
Cardiovascular diseases are characterized by sudden onset, high mortality rates, and high recurrence rates, making early screening and timely intervention essential. However, due to insufficient medical resources, real-time and refined electrocardiogram monitoring of patients is difficult to implement. Meanwhile, the complex spatiotemporal features of electrocardiogram (ECG) signals bring challenges to multidimensional feature mining and accurate recognition. Therefore, in this study, we propose a three-level risk stratification algorithm for arrhythmia, which not only ensures precise intervention for different types of arrhythmias to achieve optimized allocation of medical resources but also comprehensively captures the spatiotemporal features of ECG signals for high-accuracy risk stratification detection. The algorithm first proposes a three-level arrhythmia risk stratification scheme, classifying cases as Normal, Not Life-threatening, and Life-threatening, with corresponding intervention measures of no need for monitoring, close attention, and immediate intervention, respectively. The core model of this algorithm is a deep learning fusion network based on the palindromic structure of Convolutional Neural Network (CNN) and Long Short-Term Memory network (LSTM), which enables precise three-level risk detection for all types of arrhythmias. Experimental results demonstrate that the algorithm exhibits favorable generalization performance across multiple datasets. It not only outperforms standalone CNN and LSTM models but also surpasses classical classifiers. Notably, on the 2-second ECG segments from the gold-standard dataset, it achieves an accuracy of 99.68% and a Specificity of 99.65%.The 10-fold cross-validation yields an accuracy of 99.62% ± 0.09% for 3-second segments, and patient-level validation on 10-second segments achieves an accuracy of 96.5%. The satisfactory results across varied segment lengths verify the reliability and practicality of the proposed method. In both arrhythmia risk stratification and detection tasks, the algorithm presents moderate competitive advantages.
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