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Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure
Zipporah Erebholo1, Anja Karlstaedt1
1Department of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Abstract:
Metabolic alterations are a hallmark of heart failure and differ across stages. The immune system plays a critical role in cardiac repair and injury during heart failure progression. Metabolic interactions between immune cells and cardiomyocytes are critical for influencing cellular states and cell-cell communications. Understanding these molecular intersections is essential to developing targeted therapies that regulate immunometabolism in the heart. In this review, we provide a comprehensive overview of the metabolic links between immune cells and cardiomyocytes during heart failure and discuss potential treatment strategies.
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