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Published on: August 23, 2024
Visual analysis of the literature on postmenopausal osteoporosis-related hormone research: Current status and future
Yongjin Li1, Bo Jin1, Kunjian Li1
1Graduate School of Guangxi University of Chinese Medicine, Nanning, China.
Background:
Postmenopausal osteoporosis (PMOP) is a metabolic bone disease characterized by decreased bone mass and deteriorated bone microstructure. Despite advancements in hormone-related PMOP research, a systematic bibliometric analysis in this domain remains absent.
Objective:
This study employs bibliometric methods to delineate global trends, key contributors, and research hotspots in PMOP-related hormone studies (2004-2024), providing evidence-based guidance for future investigations.
Study Design:
A comprehensive analysis was conducted using 2004 to 2024 literature systematically retrieved from the Web of Science Core Collection database, focusing on PMOP-hormone interactions.
Methods:
CiteSpace (6.3.R1) facilitated multidimensional analyses of countries, institutions, authors, journals, co-cited references, and keywords. Network optimization utilized g-index (k = 25) node filtering and the PathFinder algorithm for structural refinement.
Results:
Among 7174 analyzed publications, China and the United States dominated research output (46.94% combined). Leading institutions included the University of California System and Harvard University, with Osteoporosis International as the most active journal. Keyword clustering revealed emerging hotspots: oxidative stress (cluster #0), vitamin D deficiency, and romosozumab, demonstrating the centrality of estrogen receptor-related studies.
Conclusion:
This pioneering bibliometric study establishes a knowledge mapping framework for PMOP-hormone research, elucidating multidimensional associations between hormonal regulation and bone metabolism. Findings underscore oxidative stress-hormone axis modulation and romosozumab-targeted therapies as critical frontiers, while emphasizing the imperative for enhanced interdisciplinary collaboration to advance therapeutic innovation.
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