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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...

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Related Experiment Video

Updated: Jul 12, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Cadmium Toxicity to the Animal Reproductive Systems: A Narrative Review.

Honghan Ye1,2, Ao Sun2, Renke Hu2

  • 1College of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi, China.

Journal of Applied Toxicology : JAT
|July 11, 2026
PubMed
Summary

Cadmium exposure harms animal reproductive health and can cause multigenerational harm to offspring. This review examines cadmium

Keywords:
cadmiumexperimental animal modelsintergenerationaloffspringovaryreproductive performancetestistoxicitytransgenerational

Related Experiment Videos

Last Updated: Jul 12, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Area of Science:

  • Environmental toxicology
  • Reproductive biology
  • Developmental toxicology

Background:

  • Cadmium, a heavy metal from industrial processes, contaminates the environment and accumulates in plants.
  • Animals consuming contaminated plants accumulate cadmium, leading to organ damage and impaired reproductive fitness.
  • Emerging research indicates cadmium exposure can cause transgenerational reproductive harm.

Purpose of the Study:

  • To review cadmium's disruption of male and female reproductive systems.
  • To examine multigenerational effects of parental cadmium exposure on offspring reproductive health.
  • To identify common themes, biological pathways, and knowledge gaps in cadmium's transgenerational toxicity.

Main Methods:

  • Literature review of studies on cadmium's reproductive and transgenerational effects in animals.
  • Analysis of common themes across different animal models.
  • Identification of potential biological pathways for multigenerational toxicity.

Main Results:

  • Cadmium exposure induces reproductive system damage in parent animals.
  • Parental cadmium exposure leads to adverse reproductive health outcomes in offspring.
  • Evidence suggests specific biological pathways mediate transgenerational cadmium toxicity.

Conclusions:

  • Cadmium poses a significant risk to animal reproductive health across generations.
  • Understanding transgenerational cadmium toxicity mechanisms is crucial for risk assessment.
  • Further research is recommended to elucidate transmission pathways and inform protective strategies.