Dupuytren's disease: a state-of-the-art review

Area of Science:

• Hand Surgery
• Rheumatology
• Dermatology

Background:

• Dupuytren's disease (DD) is a prevalent chronic hand condition characterized by fibrotic nodules and progressive digit flexion.
• It significantly impairs hand function, daily activities, and quality of life for affected individuals worldwide.
• Current management primarily focuses on corrective measures, lacking direct intervention in underlying disease mechanisms.

Purpose of the Study:

• To review the epidemiology and risk factors of Dupuytren's disease.
• To summarize the latest research on the biological mechanisms driving DD progression.
• To discuss current non-surgical and surgical treatment options and future directions for early-stage DD.

Main Methods:

• Literature review of epidemiological data, risk factors, and pathogenetic mechanisms of Dupuytren's disease.
• Synthesis of information on current non-surgical and surgical interventions.
• Analysis of emerging research and future treatment strategies for early-stage DD.

Main Results:

• Dupuytren's disease affects patients globally, with identifiable risk factors contributing to its development.
• Research is increasingly elucidating the complex biological pathways involved in DD pathogenesis and progression.
• A range of corrective treatments exist, from non-surgical options for early stages to surgical interventions for advanced disease.

Conclusions:

• Effective management of Dupuytren's disease requires a deeper understanding of its biological underpinnings.
• While current treatments are corrective, future strategies may focus on modulating disease progression.
• Further research into early-stage interventions holds promise for improving long-term patient outcomes.