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Published on: April 21, 2019

Pediatric drug allergy: a retrospective analysis of clinical features, laboratory parameters, and systemic

Filiz Demir Şahin1, Ozan Kapçay2, Mehmet Kılıç2

  • 1Department of Pediatric Immunology and Allergy, Faculty of Medicine, Fırat University, Elâzığ, Turkey; fdsahin@firat.edu.tr.

Allergologia Et Immunopathologia
|July 11, 2026
PubMed

Insights

Hematological parameters like neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) may help predict drug hypersensitivity reactions (DHRs) in children. These inflammatory indices require further validation in larger studies.

Area of Science:

  • Pediatric Allergy and Immunology
  • Hematology
  • Clinical Biomarkers

Background:

  • Drug hypersensitivity reactions (DHRs) pose a significant challenge in pediatric care.
  • Identifying reliable biomarkers for early detection and risk stratification of DHRs is crucial.

Purpose of the Study:

  • To evaluate the potential of hematological parameters and systemic inflammatory indices as predictive biomarkers for DHRs in pediatric patients.
  • To analyze specific indices like neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), and systemic immune-inflammation index (SII).

Main Methods:

  • Retrospective review of medical records of children with suspected DHRs at a Pediatric Allergy and Immunology Clinic.
  • Analysis of demographic data, clinical features, complete blood counts, and total immunoglobulin E (IgE) levels.
  • Calculation and comparison of inflammatory indices (NLR, PLR, ELR, SII) between patients with confirmed DHRs and controls.

Main Results:

  • Drug allergy was confirmed in 31.1% of the 45 included children.
  • Significantly higher monocyte counts and elevated NLR, PLR, and SII were observed in children with confirmed DHRs.
  • Significantly lower lymphocyte and basophil counts were noted in the patient group, while eosinophil counts were higher in controls.

Conclusions:

  • Elevated NLR, PLR, and SII may serve as potential indicators for DHRs in pediatric patients.
  • These hematological indices offer a promising avenue for hypothesis generation and tentative risk stratification.
  • Further validation in larger, prospective studies is essential to confirm these preliminary findings.
Abstract

Keywords:
drug hypersensitivity reactionsinflammatory biomarkerspediatric drug allergy

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