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Related Experiment Video

Updated: Jul 12, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Semiautomated Volumetric Hemorrhage Quantification Using High-Frequency Ultrasound Following Spinal Cord Injury.

Aysha Allard Brown1, Kitty So1, Juliana Mitchell1

  • 1International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC), Vancouver, Canada.

Journal of Neurotrauma
|July 11, 2026
PubMed
Summary

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The Journal of physiology·2026

Intraparenchymal hemorrhage (IPH) expands rapidly in the hours after spinal cord injury (SCI), particularly in dorsal and ventral areas. A new semiautomated ultrasound method accurately quantifies this early IPH progression in preclinical models.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Radiology

Background:

  • Intraparenchymal hemorrhage (IPH) exacerbates secondary injury after traumatic spinal cord injury (SCI).
  • Assessing IPH progression in humans is challenging, necessitating preclinical models for detailed study.
  • Early IPH characterization is crucial for understanding injury mechanisms and developing treatments.

Purpose of the Study:

  • To characterize IPH progression within 7 hours post-SCI using high-frequency ultrasound (US) in a porcine model.
  • To develop and validate a semiautomated US-based method for quantifying IPH volume and extent.
  • To assess the reliability of the semiautomated method for IPH measurement.

Main Methods:

  • Seventeen Yucatan miniature pigs underwent weight-drop contusion-compression SCI.
Keywords:
hemorrhagemanual segmentationporcine modelsemiautomated segmentationspinal cord injuryultrasound

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Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury
09:19

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

Published on: May 7, 2015

Related Experiment Videos

Last Updated: Jul 12, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury
09:19

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

Published on: May 7, 2015

  • Serial intraoperative US scans were performed up to 7 hours post-injury, with a final scan at 7 days.
  • A semiautomated segmentation approach was developed and validated against histological analysis (hematoxylin and eosin staining).
  • Inter-rater and intra-rater reliability assessments were conducted.

    • Main Results:

    • IPH was consistently observed across all time points post-SCI.
    • IPH expansion (volume and length) occurred immediately post-injury, peaking at 0.5 hours and continuing up to 7 hours.
    • Expansion primarily occurred axially in dorsal and ventral directions, not rostral-caudally.
    • The semiautomated method showed excellent inter-rater and intra-rater reliability, outperforming manual segmentation.

    Conclusions:

    • Distinct regional patterns of IPH expansion occur in early hours post-SCI, especially dorsally and ventrally.
    • IPH expansion did not plateau by 7 hours post-injury.
    • The semiautomated US quantification method offers an accurate and objective tool for IPH assessment in SCI research.