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Related Experiment Video

Updated: Jul 12, 2026

Point-of-Care Lung Ultrasound in Adults: Image Acquisition
09:17

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Over- and underscreening for lung cancer.

Hang Cao1,2,3, Yang Zhang1,2,3, Fangqiu Fu1,2,3

  • 1Department of Thoracic Surgery and State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University Shanghai Cancer Center, Shanghai, China.

Translational Lung Cancer Research
|July 11, 2026
PubMed
Summary

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Current lung cancer screening using low-dose computed tomography (LDCT) faces challenges due to diverse tumor biology. Adaptive strategies, like "low-age, low-frequency" screening, may improve outcomes and efficiency.

Area of Science:

  • Pulmonary Medicine
  • Oncology
  • Radiology

Background:

  • Low-dose computed tomography (LDCT) has improved lung cancer survival but faces implementation challenges.
  • Current screening paradigms may not fully address the diverse nature of lung cancer, including differences between Western and Eastern populations.

Purpose of the Study:

  • To review clinical discrepancies in LDCT implementation.
  • To explore adaptive screening frameworks for lung cancer.
  • To identify drivers of misalignment between current screening and tumor biology.

Main Methods:

  • Synthesis of clinical screening outcomes.
  • Investigation of lung tumor natural history.
  • Analysis of disparities in screening effectiveness across different cohorts.
Keywords:
Low-dose computed tomography (LDCT)early detectionlung cancerover & underscreening

Related Experiment Videos

Last Updated: Jul 12, 2026

Point-of-Care Lung Ultrasound in Adults: Image Acquisition
09:17

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Main Results:

  • Significant disparities exist between Western and East Asian cohorts regarding lung cancer presentation and nodule types (e.g., ground-glass nodules).
  • Lung cancer exhibits diverse evolutionary trajectories, from indolent to aggressive subtypes with narrow "curative time windows".
  • A screening paradox of overscreening and underscreening exists due to a mismatch between smoking-centric protocols and biological realities.

Conclusions:

  • Current smoking-centric guidelines may lack the flexibility for lung cancer's biological and epidemiological diversity.
  • Risk-adapted screening frameworks, such as a "low-age, low-frequency" strategy, are proposed to optimize outcomes and efficiency.
  • Prospective validation of adaptive screening strategies is warranted.