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Sanjad-Sakati Syndrome in Jordan: Clinical Features, Comorbidities, and Mortality Rate
Abdelrazaq Ahmad Alyasin1, Fadi Ayyash1, Hadeel Al Qurieny1
1Pediatric Endocrine and Diabetes Department, Queen Rania Al Abdullah Hospital for Children, King Hussein Medical Center, Amman, Jordan.
Avicenna Journal of Medicine
|July 11, 2026
Summary
Sanjad-Sakati Syndrome (SSS) in Jordan causes hypoparathyroidism, growth failure, and intellectual disability. Comorbidities like nephrocalcinosis increase mortality, highlighting the need for comprehensive care.
Area of Science:
- Pediatric Endocrinology
- Genetics
- Rare Diseases
Background:
- Sanjad-Sakati Syndrome (SSS) is a rare autosomal recessive disorder.
- Characterized by congenital hypoparathyroidism, dysmorphic features, and severe growth failure.
Purpose of the Study:
- To examine the clinical presentation of SSS in Jordan.
- To investigate comorbidities and mortality rates associated with SSS.
Main Methods:
- Retrospective study of 22 patients diagnosed with SSS in Jordan (2002-2025).
- Evaluation of demographic data, growth, biochemical findings, comorbidities, and mortality.
Main Results:
- All patients exhibited low birth weight, dysmorphic features, hypocalcemia, congenital hypoparathyroidism, and short stature.
- Common comorbidities included nephrocalcinosis (31.8%), intestinal pseudo-obstruction (22.7%), and subclinical hypothyroidism (9.1%).
- Mortality rate was 45.5%, primarily due to pneumonia and sepsis.
Conclusions:
- SSS in Jordan presents with consistent congenital hypoparathyroidism, developmental delay, intellectual disability, and severe growth failure.
- Nephrocalcinosis, dental anomalies, and intestinal pseudo-obstruction are frequent comorbidities.
- Comorbidities significantly increase the mortality rate in SSS patients.
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