Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DMTMM-mediated synthesis of norbornene-modified hyaluronic acid polymers to probe cell-hydrogel interactions.

Carbohydrate polymer technologies and applications·2026
Same author

The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a during postnatal development.

Development (Cambridge, England)·2026
Same author

Reprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes.

bioRxiv : the preprint server for biology·2026
Same author

Magnetoactive hydrogels to probe curvature-directed endothelial cell mechanosensing.

bioRxiv : the preprint server for biology·2026
Same author

Protocol for preparing tyramine functionalized hyaluronic acid via aqueous DMTMM-mediated conjugation.

STAR protocols·2026
Same author

Mechanical Cues Regulate Estrogen and Progesterone-Induced Nascent ECM Deposition by Human Endometrial Stromal Fibroblasts.

Journal of biomedical materials research. Part A·2026

Related Experiment Video

Updated: Jul 12, 2026

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
08:23

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel

Published on: October 13, 2018

Nascent extracellular matrix: the missing piece in hydrogel design.

Joshua Yu-Chung Liu1,2, Matthew L Tan3, Claudia Loebel1,2,3

  • 1Department of Bioengineering, University of Pennsylvania, Pennsylvania, 19104, USA.

Cell Biomaterials
|July 11, 2026
PubMed
Summary

Cells rapidly deposit nascent extracellular matrix (nECM) that influences their fate. This perspective outlines methods for studying nECM and proposes engineering strategies to control cell-matrix interactions.

Keywords:
Extracellular matrixcell culturecell-matrix interactionshydrogelprotein engineering

More Related Videos

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs
07:48

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Published on: May 5, 2023

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
07:12

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

Related Experiment Videos

Last Updated: Jul 12, 2026

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
08:23

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel

Published on: October 13, 2018

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs
07:48

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Published on: May 5, 2023

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
07:12

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • The extracellular matrix (ECM) is crucial for cell and tissue fate.
  • Engineered hydrogels mimic ECM properties but often overlook cell-secreted nECM.
  • Nascent ECM (nECM) deposited by cells significantly impacts cell behavior.

Purpose of the Study:

  • To highlight the role of nECM in regulating cell fate.
  • To provide guidelines for studying nECM.
  • To propose methods for engineering nECM to control cell-matrix interactions.

Main Methods:

  • Review of key studies on nECM's role in cell fate.
  • Guidelines for nECM investigation using spatiotemporal mapping, mechanical/structural, biochemical, and functional assays.
  • Proposal of chemical and protein engineering approaches for nECM modification.

Main Results:

  • nECM accumulates at the cell-hydrogel interface.
  • nECM acts as a critical regulator of cell fate.
  • Existing hydrogel engineering tools can be adapted for nECM engineering.

Conclusions:

  • Understanding and engineering nECM is essential for advanced biomaterial design.
  • Spatiotemporal mapping and characterization are key to studying nECM.
  • Targeted engineering of nECM offers precise control over cell-matrix interactions.