Related Experiment Videos
Clinical and prognostic implications of pituitary tumor-transforming gene 1 in solid tumors
Peng Dong1, Weiguang Zhou2, Longhui Xiong2
1Department of General Surgery, the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Background:
Pituitary tumor-transforming 1 (PTTG1) plays a crucial role in cancer pathogenesis and has been associated with survival outcomes and clinicopathological features in patients with various tumors. Therefore, we conducted a comprehensive meta-analysis to evaluate the prognostic and clinicopathological significance of PTTG1 expression in solid tumors.
Methods:
A comprehensive search of the PubMed, EMBASE and Web of Science was performed to identify eligible studies until July 20, 2025. The hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Stata SE 12.0 software was used to perform the meta-analysis.
Results:
22 studies from 21 articles were included in this meta-analysis. The pooled results showed that patients with high PTTG1 expression had poorer overall survival (OS)(HR:1.85,95%CI:1.55-2.20) and disease-free survival/recurrence-free survival (DFS/RFS) (HR:3.48, 95%CI:1.81-6.70). Subgroup analysis showed that high PTTG1 expression was mainly associated with worse OS in renal cell carcinoma(RCC),non-small cell lung cancer(NSCLC),breast cancer(BC), esophageal squamous cell carcinoma(ESCC) and laryngeal cancer(LRGC). Furthermore, high PTTG1 expression was significantly associated with tumor stage (III-IV vs I-II), T stage (T3-4 vs T1-2), lymphatic invasion(Yes vs No) and metastasis (Yes vs No).
Conclusion:
PTTG1 may serve as a prognostic indicator in specific cancers.
Related Concept Videos
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Abnormal Proliferation
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...