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Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal

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Light therapy in medicine: where do we stand?

Yoshimasa Oyama¹, Andrea Witowski², Michael Adamzik²

¹Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Oita, Japan.

Annals of Translational Medicine

|July 11, 2026

Summary

Light therapy offers diverse medical applications, from treating seasonal affective disorder (SAD) with bright light to using UV-B for psoriasis. Evidence varies, with more research needed for emerging uses like pain management.

Keywords:

Photobiomodulation (PBM)circadian rhythms intense light organ protection

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Area of Science:

Medical disciplines
Photobiology
Chronobiology

Background:

Light therapy encompasses diverse interventions with varying clinical validation.
Mechanisms of light therapy depend on wavelength, delivery, and target.
Distinguishing validated uses from exploratory and preclinical research is crucial.

Purpose of the Study:

To review the current state of light therapy across medical fields.
To differentiate established clinical applications from emerging ones.
To highlight the evidence hierarchy for guiding research and clinical translation.

Main Methods:

Systematic review of light therapy applications and mechanisms.
Evaluation of clinical evidence supporting different light therapy modalities.
Analysis of biological pathways, including circadian and mitochondrial effects.

Main Results:

Bright light therapy is validated for SAD; UV-B for psoriasis.
Moderate evidence supports dermatological and sleep applications.
Emerging uses in pain, injury, and infection require further clinical trials.

Conclusions:

Light therapy is generally safe with established protocols.
Clinical relevance of some proposed mechanisms, like PER2 activation, needs investigation.
Prioritizing evidence-based research is key for advancing light therapy.