Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 13, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Nanoplatforms for Sentinel and Tumor-Draining Lymph Node Mapping: From Visualization to Pathway-Informed Staging.

Xu Chen1, Nina Li1, Meiyan Zou1

  • 1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.

Advanced Healthcare Materials
|July 11, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-Translational Regulation of CD8<sup>+</sup> T Cell Fate and Dysfunction in Tumor Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17-Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Smoking-induced microbial dysbiosis: a key driver of systemic diseases and emerging therapeutic opportunities.

Cell death discovery·2025
Same author

Decoding MHC loss: Molecular mechanisms and implications for immune resistance in cancer.

Clinical and translational medicine·2025
Same author

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Metabolic gatekeepers: harnessing tumor-derived metabolites to optimize T cell-based immunotherapy efficacy in the tumor microenvironment.

Cell death & disease·2024

Nanoparticle lymphatic tracers improve sentinel lymph node (SLN) and tumor-draining lymph node (TDLN) identification. These advanced materials offer enhanced precision and reliability for cancer staging and surgical planning.

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Accurate sentinel lymph node (SLN) and tumor-draining lymph node (TDLN) identification is critical for cancer staging and treatment decisions.
  • Conventional radiotracer and dye methods have limitations in specificity, workflow flexibility, and reliability, especially in complex lymphatic systems.

Purpose of the Study:

  • To review recent advances in nanoparticle-based lymphatic tracers for improved SLN and TDLN detection.
  • To analyze how nanoparticle properties and contrast mechanisms enhance imaging performance for clinical application.

Main Methods:

  • Review of recent literature on various nanoparticle types (carbon-based, magnetic, metal/metal-oxide, polymeric/organic, bio-derived/biomimetic).
  • Emphasis on material composition, surface engineering, and physical contrast mechanisms.
Keywords:
lymphatic mappingmultimodal imagingnanoparticle tracerssentinel lymph nodestumor‐draining lymph nodes

More Related Videos

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

Related Experiment Videos

Last Updated: Jul 13, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

  • Synthesis of design principles for sensitive detection, metastatic discrimination, and workflow robustness.

    • Main Results:

    • Nanoparticle tracers offer controllable transport, stable retention, and multimodal signal generation for SLN/TDLN detection.
    • Advances focus on sensitive detection of occult nodes and accurate discrimination of metastatic involvement.
    • Nanoparticles demonstrate robustness in delayed surgery, neoadjuvant therapy, and complex clinical workflows.

    Conclusions:

    • Lymphotropic nanoparticles represent a promising platform for enhancing the accuracy and operational scope of SLN/TDLN assessment.
    • These advancements address limitations of conventional tracers, improving cancer staging and surgical decision-making.
    • Nanoparticle-based approaches offer mechanistically grounded and clinically relevant improvements in lymphatic mapping.