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Updated: Jul 13, 2026
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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Intelligent detection technologies for microbes and disease biomarkers
Shuang Liu1, Yanhua Yang1, Ye Pan1
1School of Biological Science and Technology, Jiangsu University, Zhenjiang, China.
Critical Reviews in Microbiology
|July 11, 2026
Summary
Advanced detection technologies offer noninvasive, real-time monitoring of microbes and disease biomarkers. These innovations promise breakthroughs in precision medicine and personalized health by overcoming limitations of conventional methods.
Area of Science:
- Microbiology
- Biotechnology
- Medical Imaging
Background:
- Microbial metabolic activities are crucial in human health and disease pathogenesis.
- Conventional microbe and biomarker detection methods face limitations in real-time performance, invasiveness, specificity, and parallel detection.
- Emerging interdisciplinary fields are driving the development of intelligent detection technologies.
Purpose of the Study:
- To systematically review technological breakthroughs for microbial visualization and disease biomarker tracking.
- To highlight novel solutions for sensitive, noninvasive, real-time, and multi-modal detection.
- To discuss challenges in clinical translation for precision medicine and microbiome research.
Main Methods:
- Review of physical information-based sensing (photoacoustic imaging, acoustic reporter genes).
- Exploration of specific probe labeling (fluorescent, isotopic, nanomaterial-based).
- Analysis of genetically engineered biosensors and bioluminescence imaging.
Main Results:
- These advanced strategies enable real-time *in vivo* monitoring of microbial dynamics.
- The reviewed technologies show significant promise for sensitive and specific biomarker detection.
- Integration of synthetic biology, nanotechnology, optical imaging, and AI is key.
Conclusions:
- Novel intelligent detection technologies offer solutions to limitations of conventional methods.
- These approaches facilitate real-time *in vivo* microbial monitoring and biomarker detection.
- Addressing clinical translation challenges is vital for advancing precision medicine and personalized health.
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