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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
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Liver-Targeted Triple-Modal Molecular Probe for Visualization of Aging Marginal Donor Livers.

Min Zhao1,2, Yongcheng Dai3, Gang Xu1,2

  • 1Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, Liver Transplant Center, Organ Transplant Center, Department of General Surgery, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Analytical Chemistry
|July 11, 2026
PubMed
Summary

A new molecular probe, CyC, rapidly assesses liver senescence using color and imaging. This tool aids in evaluating donor livers for transplantation, potentially reducing graft discard.

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Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Hepatology

Background:

  • Assessing senescence in aging donor livers is crucial for transplantation but analytically challenging.
  • Senescence-associated β-galactosidase (β-Gal) is a key biomarker for cellular senescence.

Purpose of the Study:

  • To develop and evaluate CyC, a novel triple-modal molecular probe for rapid hepatic senescence detection.
  • To integrate naked-eye colorimetric sensing with near-infrared fluorescence/photoacoustic (NIRF/PA) imaging for senescent liver evaluation.

Main Methods:

  • CyC probe design and synthesis targeting liver senescence.
  • In vitro and in vivo testing for β-Gal activity detection using colorimetric and NIRF/PA imaging.
  • Ex vivo assessment on clinical human liver tissue samples.

Main Results:

  • CyC exhibits a turn-on NIRF/PA response and a visible blue-to-green color change upon β-Gal activation.
  • The probe demonstrates high sensitivity, specificity, efficient liver enrichment, and strong signal contrast.
  • CyC successfully detected β-Gal activity in clinical human liver samples ex vivo.

Conclusions:

  • CyC offers a practical, rapid, and instrument-free method for assessing senescence in aging donor livers.
  • This triple-modal probe integrates visual sensing with quantitative imaging, aiding intraoperative decision-making.
  • CyC has the potential to expand the safe utilization of marginal donor livers in transplantation.