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Related Experiment Video

Updated: Jul 13, 2026

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

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Published on: February 18, 2022

Decreasing Radial Peripapillary Capillary Perfusion Density Correlated With Visual Field Impairment in High Myopia.

Chen Pan1,2, Yuxin Ji1, Yilei Shao1

  • 1National Clinical Research Centre for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
|July 11, 2026
PubMed
Summary

Radial peripapillary capillary (RPC) perfusion density is a more sensitive indicator of visual field defects in high myopia than peripapillary retinal nerve fibre layer (pRNFL) thickness. This finding highlights potential new diagnostic markers for myopia-related vision loss.

Keywords:
High myopiaOptical coherence tomography angiographyRadial peripapillary capillary perfusion densityVisual field impairment

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Doppler Optical Coherence Tomography of Retinal Circulation
10:46

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Published on: September 18, 2012

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Neuroscience

Background:

  • High myopia is associated with structural and microvascular changes in the optic nerve head.
  • These changes can lead to visual field defects, impacting patient quality of life.

Purpose of the Study:

  • To quantify structural (peripapillary retinal nerve fibre layer thickness) and microvascular (radial peripapillary capillary perfusion density) alterations in the optic nerve head of individuals with high myopia.
  • To correlate these measured parameters with the severity of visual field mean sensitivity defect.

Main Methods:

  • A comparative analysis was performed on 32 control eyes and 53 eyes with high myopia.
  • Quantification of peripapillary retinal nerve fibre layer (pRNFL) thickness and radial peripapillary capillary (RPC) perfusion density using advanced imaging techniques.
  • Correlation analysis between structural/microvascular parameters and visual field mean deviation (MD); Receiver operating characteristic (ROC) curves were employed to assess diagnostic accuracy.

Main Results:

  • High myopia eyes exhibited significantly lower global RPC perfusion density and pRNFL thickness compared to controls (p < 0.01).
  • RPC perfusion density demonstrated higher diagnostic accuracy (AUC=0.83) in discriminating high myopia from controls than pRNFL thickness (AUC=0.63).
  • RPC perfusion density was a more sensitive indicator (AUC=0.74) for detecting visual field defects (MD < -2 dB) compared to pRNFL thickness (p=0.20). A stronger correlation was found between RPC perfusion density and MD (r=0.41) in high myopic eyes.

Conclusions:

  • Peripapillary structural and microvascular alterations are characteristic of high myopia.
  • A marked decrease in RPC perfusion density is observed, suggesting it may serve as a more sensitive biomarker for identifying visual field defects in high myopia.
  • These findings underscore the potential of microvascular assessment in the early detection and management of vision impairment in high myopia.