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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jul 13, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Intestinal Fibrosis in IBD: Rethinking the Inflammatory Paradigm and Emerging Therapeutic Opportunities.

Weihao Wang1,2, Yili Sun3,4,5, Jia Li1,2,6

  • 1School of Pharmacy, Shandong Second Medical University, Weifang, 261053, Shandong, China.

Digestive Diseases and Sciences
|July 11, 2026
PubMed
Summary
This summary is machine-generated.

Intestinal fibrosis, a severe complication of inflammatory bowel disease (IBD), involves excessive extracellular matrix (ECM) deposition. Understanding its cellular and molecular mechanisms is crucial for developing targeted anti-fibrotic therapies.

Keywords:
Cellular and molecular mechanismsInflammatory bowel diseaseIntestinal fibrosis

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Last Updated: Jul 13, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Published on: October 14, 2025

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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

Area of Science:

  • Gastroenterology
  • Pathology
  • Immunology

Background:

  • Intestinal fibrosis, a hallmark of inflammatory bowel disease (IBD) progression, results from excessive extracellular matrix (ECM) deposition.
  • This pathological process leads to intestinal wall remodeling, dysfunction, and irreversible damage like strictures, significantly impacting patient quality of life.
  • Current treatments for intestinal fibrosis, including pharmacotherapy and surgery, offer limited efficacy and do not directly address the underlying fibrotic mechanisms.

Purpose of the Study:

  • To systematically review the cellular and molecular mechanisms driving intestinal fibrosis.
  • To highlight the roles of fibroblast activation, epithelial-mesenchymal transition, and immune microenvironment in fibrosis.
  • To provide a foundation for developing targeted anti-fibrotic therapies and optimizing clinical strategies for IBD-related fibrosis.

Main Methods:

  • Systematic literature review.
  • Analysis of cellular pathways involved in fibrosis.
  • Examination of molecular mechanisms in ECM synthesis and deposition.
  • Evaluation of immune cell contributions to the fibrotic microenvironment.

Main Results:

  • Fibrosis is characterized by pathological thickening of the muscularis propria due to aberrant ECM accumulation.
  • Fibroblast activation, epithelial-mesenchymal transition, and immune dysregulation are key drivers of intestinal fibrosis.
  • Existing therapies primarily manage inflammation, not directly inhibiting or reversing fibrosis.

Conclusions:

  • A comprehensive understanding of intestinal fibrosis mechanisms is essential for therapeutic advancement.
  • Targeting fibroblast activation, EMT, and immune modulation holds promise for novel anti-fibrotic treatments.
  • Further research into these mechanisms can lead to improved strategies for managing IBD-associated intestinal fibrosis.