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Scalp Acupuncture Combined with Mouse Nerve Growth Factor Acupoint Injection for Post-stroke Cognitive Impairment
Huating Zhou1,2, Ming Li1,2, Yabo Liu1,2
1Department of Rehabilitation Medicine, Jingzhou First People's Hospital, Jingzhou, 434000, Hubei, P.R. China.
Journal of Molecular Neuroscience : MN
|July 11, 2026
Summary
Triple therapy combining cognitive training, scalp acupuncture, and mouse nerve growth factor (mNGF) injections significantly improved cognitive function and daily living abilities in patients with post-stroke cognitive impairment (PSCI). This approach offers superior rehabilitation outcomes compared to conventional training alone or with scalp acupuncture.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Integrative Medicine
Background:
- Post-stroke cognitive impairment (PSCI) significantly hinders rehabilitation effectiveness and patient quality of life.
- There is a critical need for safe and effective interventions to address PSCI.
- Conventional cognitive training shows promise but may not be sufficient for optimal recovery.
Purpose of the Study:
- To evaluate the efficacy of a novel triple therapy for PSCI.
- To compare the effectiveness of conventional cognitive training, scalp acupuncture plus conventional training, and a combination of conventional training, scalp acupuncture, and mouse nerve growth factor (mNGF) acupoint injection.
Main Methods:
- Eighty-four patients with PSCI were randomized into three groups (n=28 each).
- Group A received conventional cognitive training.
- Group B received conventional training plus scalp acupuncture.
- Group C received conventional training, scalp acupuncture, and mNGF acupoint injection.
- Interventions lasted for 4 weeks.
- Cognitive function (MoCA), activities of daily living (ADL), self-care ability (MBI), and motor function (FMA) were assessed.
Main Results:
- All groups showed significant improvements in MoCA, ADL, MBI, and FMA scores post-intervention.
- Group C demonstrated superior cognitive improvement (MoCA scores) compared to Group A and B (P < 0.003).
- Group C exhibited the best independence in ADL and significant improvements in motor function (FMA) and self-care (MBI) compared to other groups (P < 0.001).
Conclusions:
- Conventional cognitive training benefits patients with PSCI.
- Scalp acupuncture combined with conventional training enhances rehabilitation outcomes.
- The triple therapy (conventional training, scalp acupuncture, and mNGF acupoint injection) provides the most significant improvements in cognitive, functional, and motor recovery for PSCI patients, indicating high clinical value.