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Related Experiment Video

Updated: Jul 13, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Cognitive-behavioral therapy for post COVID-19 condition: A pilot randomized controlled trial.

Karoline Sophie Sauer¹, Anne-Kathrin Bräscher¹, Sylvan Germer¹

¹Department of Clinical Psychology, Psychotherapy, and Experimental Psychopathology, Johannes Gutenberg University Mainz, Wallstraße 3, 55122 Mainz, Germany.

Journal of Psychosomatic Research

|July 11, 2026

Summary

Cognitive-behavioral therapy (CBT) shows promise for treating post COVID-19 condition (PCC) symptoms, including fatigue. This pilot study found CBT feasible and effective in reducing fatigue and somatic symptoms in PCC patients.

Keywords:

COVID-19 Cognitive-behavioral therapy Post COVID-19 condition

Related Experiment Videos

Last Updated: Jul 13, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Area of Science:

Neurology
Psychiatry
Rehabilitation

Background:

Post COVID-19 condition (PCC) is a significant cause of disability, necessitating effective treatments.
A pilot randomized controlled trial was conducted to assess the feasibility and efficacy of cognitive-behavioral therapy (CBT) for PCC.

Purpose of the Study:

To evaluate the feasibility and preliminary efficacy of CBT in managing PCC symptoms.
To examine the impact of CBT on fatigue, somatic symptom burden, and respiratory/cardiovascular symptoms in individuals with PCC.

Main Methods:

A parallel-group randomized controlled trial involving 52 participants with PCC.
Participants were allocated to either CBT (n=27) or a 16-week wait-list control (WLC) group (n=25).
CBT involved group and individual sessions targeting symptom maintenance; outcomes assessed included fatigue, somatic symptoms, and respiratory/cardiovascular symptoms.

Main Results:

CBT significantly reduced fatigue post-treatment compared to the WLC group (medium effect size).
The WLC group experienced a significant increase in overall somatic symptoms.
Feasibility and treatment satisfaction were reported as good, with minimal adverse effects.

Conclusions:

This pilot trial indicates that CBT is a feasible and potentially effective treatment for PCC.
Larger randomized controlled trials (RCTs) with active control groups are recommended to validate these findings.