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Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...

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Related Experiment Video

Updated: Jul 13, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression.

Ruijiang Zeng1,2,3,4, Mengmeng Wang5, Kang Wang6

  • 1Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 11, 2026
PubMed
Summary

Depression increases hepatocellular carcinoma (HCC) risk. Psychological stress elevates taurocholate, a metabolite promoting HCC growth by stabilizing CBX5. Ursodeoxycholic acid (UDCA) may offer a therapeutic strategy.

Keywords:
CBX5ferroptosispsychological stresssocial isolationtaurocholate

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Last Updated: Jul 13, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Area of Science:

  • Oncology
  • Metabolomics
  • Psychoneuroimmunology

Background:

  • Psychological stress, especially depression, is a known factor in cancer progression.
  • The specific role of depression in hepatocellular carcinoma (HCC) development and progression is not well understood.
  • Understanding the molecular mechanisms linking psychological stress to HCC is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the association between depression and hepatocellular carcinoma (HCC) risk.
  • To elucidate the molecular mechanisms underlying the link between psychological stress and HCC progression.
  • To identify potential therapeutic targets for HCC associated with psychological stress.

Main Methods:

  • Integration of three large prospective cohorts (CHARLS, NHANES, UK Biobank) for epidemiological analysis.
  • Multi-omics analyses and social isolation (SI) models using patient samples.
  • Investigated the role of metabolites, protein interactions (CBX5), and gene transcription (PHGDH) in HCC progression.

Main Results:

  • Depression was significantly associated with increased HCC risk across multiple cohorts.
  • Taurocholate was identified as a key metabolite elevated in psychological stress-associated HCC.
  • Taurocholate stabilizes CBX5, which cooperates with MYC to promote PHGDH transcription, reducing ferroptosis and enhancing tumor growth.

Conclusions:

  • A mechanistic link between depression and HCC progression via bile acid metabolic reprogramming is established.
  • The taurocholate-CBX5-MYC-PHGDH axis represents a potential therapeutic target for HCC.
  • Ursodeoxycholic acid (UDCA) demonstrated potential in suppressing tumor growth in social isolation-associated HCC models.