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Dissecting the molecular landscape of exercise-mediated protection against fructose-induced cardiac dysfunction:

Mojca Stojiljkovic¹, Snezana Tepavcevic¹, Milan Kostic¹

¹Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, Serbia.

Progress in Biophysics and Molecular Biology

|July 11, 2026

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Regular physical exercise can protect the heart from damage caused by excessive fructose intake. Exercise improves fructose metabolism and cardiac function, offering a promising non-pharmacological strategy for cardiometabolic health.

Area of Science:

Cardiology and Exercise Physiology
Metabolic Disease Research

Background:

High fructose consumption and sedentary lifestyles drive global cardiometabolic disease increase.
The evolutionary balance of fructose intake and energy expenditure is disrupted, necessitating lifestyle interventions.

Purpose of the Study:

To review the cardioprotective effects of physical exercise in the context of high fructose intake.
To explore cellular and molecular mechanisms in animal models relevant to human cardiometabolic health.

Main Methods:

Analysis of 30 PubMed-identified animal studies on fructose intake and exercise.
Focus on cellular and molecular mechanisms of exercise's impact on fructose metabolism and cardiac function.

Main Results:

Keywords:

Animal model Exercise Fructose-rich diet Heart Molecular mechanisms

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Exercise reduces fructose absorption, increases hepatic oxidation, suppresses lipogenesis, and lowers uric acid.

Improvements observed in myocardial structure, diastolic function, electrical stability, and coronary blood flow.

Benefits linked to modulation of oxidative stress, inflammation, energy metabolism, insulin signaling, and nitric oxide synthesis.

Conclusions:

Exercise is a potent non-pharmacological strategy against fructose-induced cardiac dysfunction.
Low- to moderate-intensity aerobic exercise shows significant benefits; high-intensity interval training warrants consideration.
Further human studies are needed to confirm these findings for clinical application.