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Related Experiment Video

Updated: Jul 13, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Decoding the epithelial-stromal interactome in allergic rhinitis through single-cell multi-omics integration.

Zhongzhen Liu1, Yisha Wu2, Shikai Han2

  • 1Shanxi Medical University - BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan 030001, China; State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.

The Journal of Allergy and Clinical Immunology
|July 11, 2026
PubMed

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Summary

This study reveals key cellular and molecular changes in allergic rhinitis (AR) nasal tissue, identifying aberrant epithelial cell differentiation and enhanced inflammatory crosstalk. These findings provide a molecular framework for understanding AR pathogenesis.

Area of Science:

  • Immunology
  • Genomics
  • Cell Biology

Background:

  • Allergic rhinitis (AR) is common, but its underlying cellular and molecular mechanisms are not fully understood.
  • Investigating these changes is crucial for developing targeted therapies.

Purpose of the Study:

  • To create a detailed cellular map of nasal tissue in AR and non-allergic rhinitis (NAR) patients.
  • To identify transcriptional and epigenetic changes linked to AR.

Main Methods:

  • Single-cell RNA sequencing and ATAC sequencing were performed on 39 nasal mucosa samples.
  • Multi-omics data integration using a deep learning framework for disease prediction.

Main Results:

  • A comprehensive nasal mucosa atlas of over 1 million cells was generated.
Keywords:
Allergic rhinitisEpithelial-stromal interactionGene regulatory networksNasal mucosaSingle-cell multi-omics analysesscMARIA

Related Experiment Videos

Last Updated: Jul 13, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

  • AR epithelium showed abnormal differentiation; fibroblasts exhibited inflammatory activation.
  • Enhanced epithelial-stromal communication and cell-specific epigenetic alterations were observed in AR.

    • Conclusions:

    • This multi-omics study provides a molecular framework for AR nasal mucosa.
    • Dysregulated epithelial-stromal interactions and gene networks are associated with AR.
    • The scMARIA tool aids in predicting AR risk and identifying regulatory pathways.