Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 13, 2026

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Pinpointing precision: axial length and refraction in paediatric myopia trials-a mixed methods study.

Annegret H Dahlmann-Noor1,2,3, Nick Freemantle4

  • 1UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK. Anngret.dahlmann@ucl.ac.uk.

Trials
|July 11, 2026
PubMed
Summary

Related Concept Videos

Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transition programmes for children moving from paediatric to adult eye care services: A scoping review.

European journal of ophthalmology·2026
Same author

Low concentration atropine eye drops and progression of myopia in children: multicentre placebo controlled, double masked, randomised trial in the UK (CHAMP-UK).

BMJ (Clinical research ed.)·2026
Same author

Consensus on evidence gaps and unmet needs in childhood myopia: findings from a European Delphi study with eye care professionals and payers.

BMJ open ophthalmology·2026
Same author

Asymptomatic testing compared with standard care of the care home staff in shaping care home COVID-19 testing policy: the VIVALDI-CT pragmatic cluster RCT (VIVALDI-CT).

Health and social care delivery research·2026
Same author

A systematic review and meta-analysis of the use of human albumin solution for treating the complications of liver cirrhosis.

Hepatology communications·2026
Same author

Effectiveness of Escitalopram and Nortriptyline on Depressive Symptoms in Parkinson's disease: the ADepT-PD RCT pilot.

Health technology assessment (Winchester, England)·2025

Axial length measurement is as precise as cycloplegic autorefraction for paediatric myopia trials. However, axial length is preferred due to reduced participant discomfort and improved trial efficiency.

Area of Science:

  • Ophthalmology
  • Clinical Trials
  • Paediatric Eye Care

Background:

  • Paediatric myopia intervention trials commonly use axial length and cycloplegic autorefraction as primary outcomes.
  • Standardizing primary outcomes can enhance trial efficiency, reduce participant burden, and improve retention.

Purpose of the Study:

  • To evaluate the precision of axial length and cycloplegic autorefraction in paediatric myopia trials.
  • To explore the perspectives of eye care professionals and young people regarding cycloplegia.

Main Methods:

  • A mixed-methods approach was employed, including a meta-analysis of published trial data.
  • Qualitative data were gathered through interviews with eye care professionals and discussions with children and young people.
Keywords:
AdolescentChildEfficiencyMyopiaPrecision

Related Experiment Videos

Last Updated: Jul 13, 2026

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Main Results:

  • Meta-analysis showed similar precision between axial length and cycloplegic spherical equivalent refraction.
  • Eye care professionals and young people reported significant discomfort, distress, and adverse effects associated with cycloplegia.
  • Concerns include blurred vision, light sensitivity, and potential non-attendance at follow-up appointments.

Conclusions:

  • Axial length and cycloplegic autorefraction demonstrate comparable precision in paediatric myopia trials.
  • Cycloplegic autorefraction leads to longer study visits and greater patient discomfort.
  • Future trial designs should prioritize axial length as the primary outcome to enhance efficiency and patient experience.