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Pharmacokinetic interaction between evodiamine and doxofylline in rats

Yuxian Lin1, Yongle Yang2, Wang Luo3

  • 1The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang, China/ School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong, China.

Pakistan Journal of Pharmaceutical Sciences
|July 12, 2026
PubMed
Summary

Evodiamine (EVO) significantly alters the pharmacokinetics of Doxofylline (DFL) and its metabolite, theophylline (TPL), in rats. EVO prolonged DFL retention while reducing TPL bioavailability, highlighting potential drug interactions.

Keywords:
DoxofyllineEvodiamineHPLC-MS/MSPharmacokineticsTheophylline

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