Related Experiment Video
Updated: Jul 13, 2026
04:55
Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
Published on: May 26, 2023
The extracorporeal cardiopulmonary resuscitation outcomes database
Chloe R Skidmore1, Christopher M Evola2,3, Anna L Ciullo1,2
1Division of Cardiothoracic Surgery, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
Resuscitation Plus
|July 12, 2026
Summary
Extracorporeal cardiopulmonary resuscitation (ECPR) using extracorporeal membrane oxygenation (ECMO) shows survival rates comparable to national averages, despite longer CPR times. The Extracorporeal Resuscitation Outcomes Database (EROD) is key to standardizing ECPR for better patient outcomes.
Area of Science:
- Cardiology
- Intensive Care Medicine
- Emergency Medicine
Background:
- Cardiac arrest affects over 500,000 individuals annually in the US, with low survival and neurologic recovery rates, especially for out-of-hospital events.
- Extracorporeal cardiopulmonary resuscitation (ECPR), utilizing extracorporeal membrane oxygenation (ECMO) during CPR, has seen increased application.
- The Extracorporeal Resuscitation Outcomes Database (EROD) was established to gather detailed research data on ECPR.
Purpose of the Study:
- To introduce the Extracorporeal Resuscitation Outcomes Database (EROD).
- To present the inaugural findings from the EROD registry, detailing patient characteristics, ECPR procedures, and outcomes.
- To highlight the importance of EROD in advancing ECPR research and standardization.
Main Methods:
- EROD prospectively collects data on adult cardiac arrest patients treated with ECPR.
- Data includes demographics, medical history, arrest characteristics, ECMO cannulation, post-cannulation care, hospital treatments, neuroprognostication, complications, and outcomes.
- Data was contributed by five North American centers between March 2017 and March 2022.
Main Results:
- The study included 113 patients, predominantly White (64%) and male (78%), with pre-existing medical conditions (73%).
- Most arrests occurred pre-hospital (65%) with bystander CPR (81%). Common complications included acute kidney injury (49%) and major bleeding (29%).
- Hospital survival was 25%, with an average stay of 22 days. Mean time from arrest to ECMO cannulation was 84 minutes. Survivors showed favorable neurologic outcomes (CPC 1 or 2).
Conclusions:
- The inaugural EROD report presents data from 113 patients, showing survival rates consistent with national averages.
- ECPR utilization in this cohort demonstrated acceptable outcomes despite extended CPR durations before ECMO initiation.
- The EROD registry is vital for identifying and establishing standardized ECPR protocols to optimize patient outcomes.
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