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Cholesterol metabolism and aggressive prostate cancer: clarifying the signal from EPICAP

Mario Belmonte1, Alicia López-Abad2

  • 1Department of Urological Minimally Invasive, Robotic Surgery and Kidney Transplantation, Careggi Hospital, University of Florence, Florence, Italy.

Translational Andrology and Urology
|July 12, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
EPICAP studyProstate cancercholesterol metabolismlipid-lowering therapystatins

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Cholesterol: Significance and Regulation01:29

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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