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Perioperative Pregabalin for Recurrent Intractable Hiccups: A Case Report and Literature Review
David Lei1, Craig T L Yamaguchi2, Alastair E Moody3
1Western University of Health Sciences College of Osteopathic Medicine of the Pacific, Pomona, California, USA.
Case Reports in Anesthesiology
|July 12, 2026
Summary
Pregabalin effectively managed intractable hiccups in a patient unresponsive to other treatments. This gabapentinoid shows promise for perioperative hiccup control when other therapies fail.
Area of Science:
- Anesthesiology
- Neurology
- Pharmacology
Background:
- Persistent hiccups pose significant perioperative challenges.
- Existing treatments for intractable hiccups have limited efficacy.
- Pregabalin's role in perioperative hiccup management is not well-established.
Purpose of the Study:
- To evaluate the effectiveness of pregabalin in managing refractory hiccups during the perioperative period.
Main Methods:
- A case report of a patient with a 7-year history of intractable hiccups.
- The patient received pregabalin perioperatively and postoperatively.
- Previous treatments included chlorpromazine, baclofen, gabapentin, and epidural injections.
Main Results:
- Pregabalin administration significantly reduced hiccup frequency and severity.
- The patient experienced substantial relief from intractable hiccups.
Conclusions:
- Pregabalin demonstrates potential as a treatment option for refractory hiccups in the perioperative setting.
- This case highlights pregabalin's utility when standard treatments are ineffective.
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