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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jul 13, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

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Published on: June 3, 2020

A qEEG-based prognostic model for cognitive impairment after ischemic stroke: Development and internal validation.

Vy Tuong Nguyen1,2, Trang Ho Thu Quach3, Hiep Do4

  • 1Neurology Department, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.

IBRO Neuroscience Reports
|July 12, 2026
PubMed
Summary

Early prediction of cognitive impairment after ischemic stroke is crucial. A model using occipital Delta/Alpha Ratio (DAR), frontal Peak Alpha Frequency (PAF), and education shows promise for identifying at-risk patients.

Keywords:
Cognitive impairmentDelta/Alpha RatioIschemic strokePeak Alpha FrequencyQuantitative EEG

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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

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Last Updated: Jul 13, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
06:37

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke

Published on: July 14, 2023

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Cognitive impairment is a common and debilitating outcome following ischemic stroke.
  • Current early prognostic tools for post-stroke cognitive impairment are limited.
  • Quantitative electroencephalography (qEEG) offers a portable and cost-effective method to assess cortical dysfunction after stroke.

Purpose of the Study:

  • To develop a prognostic model for predicting cognitive impairment six months after a first-ever ischemic stroke.
  • To identify early predictors of cognitive impairment using quantitative EEG parameters and demographic data.

Main Methods:

  • A prospective cohort study enrolled 96 patients with first-ever supratentorial ischemic stroke within 7 days of onset.
  • Resting-state 19-channel EEG and brain MRI were acquired at baseline.
  • Region-specific qEEG parameters (DAR, PAF) and educational attainment were analyzed using logistic regression for prediction of six-month cognitive impairment.

Main Results:

  • 46% of participants developed cognitive impairment at six months.
  • Higher occipital DAR, lower frontal PAF, and lower educational attainment were significant predictors of cognitive impairment.
  • The developed three-variable model demonstrated good internal discrimination (AUC 0.891) and calibration.

Conclusions:

  • A parsimonious three-variable model combining occipital DAR, frontal PAF, and educational attainment shows potential for predicting six-month cognitive impairment after ischemic stroke.
  • These factors serve as candidate predictors requiring further validation.
  • External, multicenter validation is essential before clinical application.